Optimal A1c for Detecting Diabetes in Early Pregnancy An HbA1c higher than 5.9% was a more accurate indicator for diabetes in pregnant patients.... Advertisement Since pregnant women are at high risk of diabetes, early intervention may be beneficial in this patient population. Currently, an HbA1c ≥6.5% (48 mmol/mol) is recommended to define diabetes in pregnancy, but this figure was based on non-pregnancy data. Using an early oral glucose tolerance test (OGTT) before 20 weeks gestation, a study was conducted to determine the optimal HbA1c threshold for detecting diabetes early on in pregnant women. Researchers also observed the relationship of pregnancy outcomes to this threshold. During 2008-2010, a total of 16,122 pregnant women in Christchurch, New Zealand were offered an HbA1c measurement with their first antenatal bloods at a median 47 days gestation. The researchers also collected pregnancy outcome data, and a subset of patients completed an early OGTT. Using World Health Organization criteria, they assessed HbA1c performance in these patients. An early OGTT was performed on 974 (23%) patients out of 4,201 patients. There were 15 cases of diabetes in this subset, and the HbA1c was ≥5.9% (41 mmol/mol) in all cases and
Posted on: Sat, 20 Sep 2014 20:11:26 +0000
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