Pathergy test. DAMS Dermatology Update: **Pathergy phenomenon is defined as a state of altered tissue reactivity that occurs in response to minor trauma like a needle prick (with a blunt needle) **Pathogenesis of pathergy phenomenon Although the exact mechanisms underlying pathergy phenomenon are unknown, skin injury caused by needle prick apparently triggers a cutaneous inflammatory response and creates a papule/pustule. This suggests an increased or aberrant release of cytokines from keratinocytes or other cells in the epidermis or dermis. The specificity of skin pathergy reaction is very high especially in Behcets disease (about 99%), especially when it is positive at 48 h Seen in 1) Behcets disease- Positive pathergy reaction is very important for the diagnosis of Behcets disease in patients with only recurrent oral ulceration plus one of the other criteria (recurrent genital ulceration, eye lesions, skin lesions). The test has also been used as an indicator of disease activity in patients with Behcets disease. It is one of the 4 minor criteria in its diagnosis 2) Pyoderma gangrenosum 3) Sweets syndrome 4) Inflammatory bowel disease 5) Eosinophilic pustular folliculitis 6) Healthy individuals
Posted on: Fri, 09 Jan 2015 08:18:17 +0000
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