Pharmacology Mechanism of Action Synthetic prostaglandin E analogue parent drug that is rapidly deesterified to misoprostol acid (active metabolite) and replaces protective prostaglandins consumed with therapies that inhibit prostaglandin synthesis; inhibits gastric acid secretion and protects gastric mucosa Significantly reduces degree of fat malabsorption in patients with >10% fat malabsorption, possibly by stimulating duodenal bicarbonate production Absorption Bioavailability: Unquantified Onset: 2-3 hr (initial response for acid secretion) Duration: ≥3 hr (inhibition of acid secretion) Peak plasma time: Misoprostol acid (active metabolite), 14 min Distribution Protein bound: Misoprostol acid (active metabolite), 80-90% Metabolism Extensive and rapid 1st-pass metabolism by liver to form misoprostol acid (active metabolite) Metabolites: Misoprostol acid (principal and active metabolite), dinor and tetranor metabolites of misoprostol acid Elimination Half-life: Misoprostol acid (active metabolite), 20-40 min Dialyzable: No Excretion: Urine (80%)
Posted on: Thu, 08 Jan 2015 03:22:31 +0000
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