Prolonged #sitting was associated with higher mortality from all causes, as well as increased incidence of cancer, cardiovascular disease, and type 2 diabetes, even among people who exercise regularly, according to a meta-analysis. The analysis of 47 previously published articles also shows that the association between all-cause mortality and sedentary behavior is greatest among people who exercise the least. 14 studies on cardiovascular disease and diabetes, 14 studies on cancer, and 13 studies on all-cause mortality, all but three of which were prospective cohort designs. All but one of the studies used participant self-reporting to track sedentary time. The increased risk for all-cause mortality was most pronounced among people with lower levels of physical activity, the authors found. The relative risk for sedentary behavior for all-cause mortality among those with high levels of physical activity was 30% lower than for those with low levels of physical activity. The hazard ratio for those who exercised frequently was 1.16 (95% CI, 0.84 - 1.59) compared with a HR of 1.46 (95% CI, 1.22 - 1.75) for those who did not. The deleterious outcome effects associated with sedentary time generally decreased in magnitude among persons who participated in higher levels of physical activity compared with lower levels. However, a study of 71,000 women aged 50 to 79 years published in the Journal of the American College of Cardiology found that low or moderate exercise levels failed to ameliorate the effect of sitting for long periods every day. Moderate exercise was defined as participating in 2 to 2.5 hours of exercise weekly. However, women who walked 7 hours each week or ran or jogged for 5 hours each week did not experience increased risk from an otherwise sedentary lifestyle, the study showed. The hazard ratio for cardiovascular events was calculated to be 1.02 per hour of time spent sitting each day (95% CI, 1.01 - 1.03).
Posted on: Thu, 22 Jan 2015 08:37:42 +0000
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