Propofol-related infusion syndrome heralding a mitochondrial - TopicsExpress

Propofol-related infusion syndrome heralding a mitochondrial disease: Case report 34m Neurology current issue by Savard, M., Dupre, N., Turgeon, A. F., Desbiens, R., Langevin, S., Brunet, D. Propofol-related infusion syndrome (PRIS) is a rare but catastrophic complication of propofol use. It is clinically characterized by metabolic acidosis, rhabdomyolysis, arrhythmias, myocardial failure, renal failure, and hepatomegaly, and may lead to death.1 Some risk factors are associated with PRIS, namely young age, critical illness, high fat intake, catecholamine or steroid use, inborn error of fatty acid oxidation, propofol doses exceeding 4–5 mg/kg/hour, and duration of use exceeding 48 hours.1 Some evidence also suggests that PRIS is related to a mitochondrial toxicity of propofol.2,3

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