Protein phosphatase 2A (PP2A) is a divalent cation-independent protein serine/threonine phosphatase involved in regulating numerous cellular processes including the cell cycle, growth and differentiation. Physiological targets of PP2A include cell surface receptors and ion channels, protein kinases involved in mitogenic signaling, the cell cycle, key regulatory enzymes and proteins involved in metabolism, as well as numerous transcription factors. The phosphatase has been implicated as a growth suppressor. It is inhibited potently by tumor promoters such as okadaic acid and by I1PP2A and I2PP2A, two naturally-occurring cancer-associated cellular proteins. Additionally, the SV40 small t antigen replaces the B subunit during viral transformation and subverts the physiological function of a subset of PP2A complexes in a substrate selective manner.
Posted on: Fri, 21 Feb 2014 19:22:14 +0000
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