Proton Pump Inhibitors Do Not Ease Crying, Fussing in - TopicsExpress

Proton Pump Inhibitors Do Not Ease Crying, Fussing in Infants by Diedtra Henderson Proton pump inhibitors (PPIs) [e.g: Prilosec, Prevacid], given to crying infants with the thinking that the discomfort of gastroesophageal reflux (GER) explains the babies tears, do not decrease crying or irritability, according to a systematic review. Dorota Gieruszczak-Bialek, MD, from the Department of Pediatrics, Medical University of Warsaw, Poland, and colleagues report the findings of their review online December 30 in the Journal of Pediatrics. In July 2104, Dr Gieruszczak-Bialek and colleagues searched two registries and three databases (MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials) for randomized controlled trials involving infants with GER or gastroesophageal reflux disease (GERD) that examined the effectiveness of PPIs. The systematic review identified 176 trials. Most were characterized by some researcher financial conflict, including support by PPI manufacturers, authors employed by PPI manufacturers, or authors with stock in companies that produce PPIs, Dr Gieruszczak-Bialek and coauthors note. Read more...

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