RPE 65 --- product of RPE gene The retinal pigment - TopicsExpress

RPE 65 --- product of RPE gene The retinal pigment epithelium-specific 65 kDa protein is located in the retinal pigment epithelium and is involved in the conversion of all-trans retinol to 11-cis retinal during phototransduction, which is then used in visual pigment regeneration in photoreceptor cells. currently targeted for the treatment of lebers congenital amaurosis ( LCA ) , retinitis pigmentosa ( RP ) and is also target by visual cycle modulator like emixustat hydrochloride for the treatment of DRY AMD. retinalphysician/articleviewer.aspx?articleID=108371

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