Robbins 9/e (Page no 319 ) (PROBABLE FOR AIIMS) EXAMPLES OF EPIGENOMIC REGULATORY GENES THAT ARE MUTATED IN CANCERS 1. DNMT3A gene------for DNA methylation e.g. Acute myeloid leukemia (20%) 2. MLL1 gene----Histone methylation e.g. Acute leukemia in infants (90%) 3. MLL2 gene ---- Histone methylation e.g. Follicular lymphoma (90%) 4. CREBBP/EP300 gene-----Histone acetylation e.g. Diffuse large B cell lymphoma (40%) 5. ARID1A gene ----- Nucleosome positioning/chromatin remodelling e.g. Ovarian clear cell carcinoma (60%) and endometrial carcinoma (30%-40%) 6. SNF5 gene---Nucleosome positioning/chromatin remodelling e.g.Malignant rhabdoid tumor (100%) 7. PBRM1 gene ---- Nucleosome positioning/chromatin remodelling e.g. Renal carcinoma (30%)
Posted on: Sat, 25 Oct 2014 17:30:07 +0000
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