Scientists identify late effects of sleep restriction: Potentiating weight gain and insulin resistance arising from a high-fat diet in mice In their latest study the researchers from the Universidade de São Paulo observed that just after sleep restriction (SR), serum insulin and resistin concentrations were increased and glycerol content decreased. In addition, resistin, TNF-α, and IL-6 mRNA expression were notably increased in epididymal fat. A t the end of the HFD period, mice previously submitted to SR gained more weight (32.3±1.0 vs. 29.4±0.7 g) with increased subcutaneous fat mass, had increments in the expression of the adipogenic genes PPARγ, C/EBPα, and C/EBPβ, and had macrophage infiltration in the epididymal adipose tissue. Furthermore, enhanced glucose tolerance and insulin resistance were also observed. The consequences of SR may last for a long period, characterizing SR as a predisposing factor for weight gain and insulin resistance. Metabolic changes during SR seem to prime adipose tissue, aggravating the harmful effects of diet-induced obesity, the Brazilian scientists conclude. suppversity | de Oliveira, E. M., Visniauskas, B., Sandri, S., Migliorini, S., Andersen, M. L., Tufik, S., Fock, R. A., Chagas, J. R. and Campa, A. (2014), Late effects of sleep restriction: Potentiating weight gain and insulin resistance arising from a high-fat diet in mice. Obesity. doi: 10.1002/oby.20970
Posted on: Thu, 08 Jan 2015 04:06:06 +0000
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