Testosterone Replacement Therapy In Hypogonadal Men: The Contribution Of Endogenous Testosterone Production While baseline T levels may affect the final T concentration, a similar proportion of patients was within the normal range and reach the therapeutic goal. [In other words, the HPTA was equally suppressed in both populations! Or, there would be a significant difference in TRT dose. What is the MOA for this result? IMO, regardless of dose exogenous androgen leads to disorder and disruption of the GnRH Pulse Generator.] Testosterone Replacement Therapy In Hypogonadal Men: The Contribution Of Endogenous Testosterone Production edrv.endojournals.org/cgi/content/meeting_abstract/34/03_MeetingAbstracts/SAT-290 Objective: This post-hoc analysis investigated the effects of endogenous testosterone (T) production reflected by baseline testosterone levels on testosterone replacement therapy (TRT) in hypogonadal men. Design: In this open-label titration trial, 2% T topical solution was applied to the axillae daily for 120 days. Dose adjustments were allowed on Days 45 and 90 to maintain T within physiological range (300 - 1050 ng/dL). Patients: Males (N = 155) over 18 years of age with hypogonadism (T < 300 ng/dL). Measurements: Serum T levels were measured at days 15, 60 and 120. Subjects were divided by T-level at baseline (T < 230 ng/dL and T 230 ng/dL). Changes in T levels and the dose of TRT required to achieve serum T level within (300 - 1050 ng/dL) were collected. Results: At baseline, 74 and 80 subjects were in the T
Posted on: Mon, 29 Jul 2013 20:23:49 +0000
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