The current hypothesis is that ROS might function as a “double-edged sword”. A moderate increase of ROS may promote cell proliferation and survival whereas an excessive increase of ROS may lead to a toxic threshold and trigger cell death. Because healthy cells maintain redox homeostasis and have lower basal levels of ROS than cancer cells, they can better tolerate a certain level of exogenous stress than cancer cells. The latter reach the critical threshold earlier and ultimately undergo cell death by apoptosis while healthy cells may survive (J. Wang et al., 2008; D. Trachootam et al., 2009). Several ROS-generating agents are currently in clinical trials as single agents or in combination therapy. enzolifesciences/science-center/technotes/2015/january/ros-an-unusual-new-ally-in-defeating-cancer/
Posted on: Fri, 09 Jan 2015 23:02:29 +0000
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