The disconcerting ability of bacteria to evade death from - TopicsExpress

The disconcerting ability of bacteria to evade death from treatment with antibiotics is achieved with two distinct strategies, resistance and tolerance. Resistance occurs by a variety of mechanisms, including drug efflux and/or preventing the drug from binding by modifying either the drug itself or its target. Tolerance, on the other hand, is a characteristic of a subpopulation of normal cells known as “persisters.” This phenomenon was first described by J. W. Bigger in 1944 who found that some members of a population of Staphylococcus aureus survived treatment with penicillin...

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