The incidence of amyloidosis is uncertain, but it is thought that the most frequently diagnosed AL amyloidosis has an annual incidence of 6 to 10 cases per million population in the United Kingdom and United States. Amyloidosis due to transthyretin deposition (ATTR) can be wild-type transthyretin amyloid deposits, which predominantly accumulate in the heart and are very common at autopsy in the elderly. Although the associated clinical syndrome known as senile systemic amyloidosis is diagnosed rarely in life,2 there is increasing evidence that this disorder is much underdiagnosed and that with increasing longevity and improved diagnostic methods it may be identified as a substantial public health problem.
Posted on: Sun, 23 Mar 2014 01:30:43 +0000
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