Triacylglycerols synthesis Phosphatidic acid + H2O → Diacylglycerol + Pi phosphatase Diacylglycerol + Acyl-CoA → Triacylglycerols + CoASH acyltransferase In the liver triacylglycerols are incorporated in VLDL. Different acyl radicals (not the same fatty acid) are incorporated in triacylglycerols. Regulation of triacylglycerols synthesis Triacylglycerols synthesis is increased in the fed state. Triacylglycerols synthesis is decreased during fasting. Insulin is a powerful stimulator of Triacylglycerols synthesis. Triacylglycerols are stored in the adipose tissue, Increase in body weight is due to increase in synthesis. Diabetics usually loose weight if their disease is not controlled. The synthesis and degradation of lipids is regulated by the energy requirements of the organism as a whole. The blood is the carrier of triacylglycerols in the form of VLDLs and chylomicrons, fatty acids bound to albumin, amino acids, lactate, ketone bodies and glucose. The pancreas is the primary organ involved in sensing the organisms dietary and energetic states by monitoring glucose concentrations in the blood. Low blood glucose stimulates the secretion of glucagon, whereas, elevated blood glucose calls for the secretion of insulin.
Posted on: Sat, 06 Dec 2014 10:20:56 +0000
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