Tumor marker- (c) Her2/neu Her2/neu is human epidermal growth factor receptor. Her2/neu is used to predict response of breast tumors in chemotherapy. Herceptin (trastuzumab) is a humanized monoclonal antibody that binds to Her2/neu and inhibits activation of the receptor, consequently breast tissue that is positive for Her2/neu are candidates for Herceptin therapy. Currently the test is best performed on breast tissue biopsy specimens. Squamous Cell Carcinoma (SCC) Antigen Fraction Serum A glycoprotein and subfraction of a tumor-associated antigen (TAA). Increased levels are associated with tumor progression or recurrence in cervical and uterine squamous cell cancer. Useful for monitoring clinical management. Terminal Deoxynucleotidyl Transferase (TDT) Peripheral blood or bone marrow Elevated in lymphoblastic leukemia and undifferentiated leukemia and in chronic myelogenous leukemia in blast crisis. Considered to be a biochemical marker for certain immature lymphocytes. Levels may increase and decrease as certain leukemia patients remit and relapse. May be helpful in the classification of leukemia and in selection and monitoring of therapy. Bladder Tumor Associated antigen (BTA) stat Test Urine The BTA test is a single step immunochromatographic assay for bladder associated antigen in voided urine. The associated antigen is a human complement factor H related protein (hCFHrp) The clinical specificity of the test is 95.9% and clinical sensitivity 40-59%. The test is superior to the voided urinary cytology in the detection of recurrent bladder cancer. It will reduce, but not eliminate, the use of cystoscopy.
Posted on: Wed, 07 Jan 2015 16:26:34 +0000
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