Update on Tumor lysis syndrome * Most commonly seen with acute leukemias, Burkitt lymphoma and other lympho-reticular malignancies. Chemotherapy results in release of massive amounts of potassium, uric acid and other breakdown products into the blood. t develops within hours to few days of initiation of chemotherapy. * Features: - hypocalcemia - renal failure due to precipitation of uric acid crystals or calcium phosphate crystals in the kidney - hyperkalemia leading to arrhythmias - hyperphosphatemia * Management - vigorous IV hydration with half normal saline - correction of metabolic abnormalities - hemodialysis in severe cases
Posted on: Thu, 20 Mar 2014 05:34:43 +0000
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