What is the best way forward for neuroscience research into psychiatric disorders? B.J.C. and F.S.L. A vertically integrative approach in which basic neuroscientists coordinate studies with psychiatric research‑ ers would be the best way to use the consid‑ erable advances in neuroscience to inform our understanding of psychiatric disorders. The framework of the RDoC project allows for such an integrative approach. For example, the effects of mutations found in humans in key candidate genes could be studied in rodents, and circuit‑based and behavioural tests in rodents could then be optimized and validated for the human con‑ dition. This would allow translation of the rodent findings to humans with and without psychiatric disorders. Moreover, this integra‑ tive approach can build bridges between, on the one hand, the relevant but complex and imprecise phenomenology of human behav‑ iour and, on the other hand, the solid find‑ ings from rodent neurobiology, which can be difficult to extrapolate to human behaviour and disease. -- Casey et al Nature Rev Neurosci 2013
Posted on: Fri, 18 Oct 2013 15:24:55 +0000
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