YAPping on #Kras addiction -> ow.ly/yPRvG, - TopicsExpress

YAPping on #Kras addiction -> ow.ly/yPRvG, ow.ly/yPRxe #Oncogene addition provides a therapeutic sweet spot for treating #cancer. Yet, tumor #relapse still occurs when this line of treatment fails. Here, two independently developed studies, one from Tyler Jacks and William Hahn at Broad Institute of MIT and Harvard and the other from Ronald DePinho and Haoqiang Ying at MD Anderson Cancer Center, both point out that the transcriptional coactivator YAP1 is a key driver compensating the loss of Kras signaling in Kras-dependent cancers. Find out how YAP1 keeps #tumor going when Kras is not an option. -> ow.ly/yPRvG, ow.ly/yPRxe. Don’t forget the Preview by Florian Greten -> ow.ly/yPRIi

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