MILK THISTLE: GOOD FOR LIVER, BAD FOR ANDROGEN RECEPTORS Excerpt: I’ve been doing some research into Milk Thistle recently, because it’s the most commonly used liver protector for steroid users. It’s sold at GNC, Vitamin Shoppe, etc…and it not only works to protect the liver, it’s also pretty cheap. For years, mediocre supplement designers have been slamming this stuff into any formula that could be liver toxic, and then forgetting about it. It’s a no-brainer (literally). People just cram the stuff in their supplements without doing any real research. The problem with Milk Thistle is that it blocks your androgen receptors, thereby making the steroids (androgens) you’re taking less effective – this is why it has been studied as a possible chemoprotective agent for androgen dependent cancers. The active component in Milk Thistle effectively reduces nuclear androgen receptor levels (click for the full study), and down-regulates several androgen-regulated genes primarily by inhibiting the transactivation activity of the AR, and can also inhibit nuclear localization of the androgen receptor. Nobody is right all of the time, and I’ve probably thought this stuff was a good idea in the past (like Llewellyn and a lot of other people), but the truth is that Milk Thistle is a bad idea for use on a cycle – at least if you want your cycl
Posted on: Mon, 29 Jul 2013 19:04:01 +0000
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