N,N-Dimethyltryptamine (DMT or N,N-DMT) is a psychedelic compound of the tryptamine family. Since DMT resembles the basic structure of neurotransmitters, when ingested, DMT is able to cross the human blood-brain-barrier, allowing it to act as a powerful hallucinogenic drug that dramatically affects human consciousness.[3] Depending on the dose and method of administration, its subjective effects can range from short-lived, milder psychedelic states to powerful immersive experiences; these are often described as a total loss of connection to external reality and an experience of encountering indescribable spiritual/alien beings and realms.[4] Indigenous Amazonian Amerindian cultures consume DMT as the primary psychoactive chemical (one that affects the mind) in ayahuasca, a shamanistic brew used for divinatory and healing purposes. In terms of pharmacology, ayahuasca combines DMT with a MAOI, an enzyme inhibitor that allows DMT to be orally active.[5] Its presence is widespread throughout the plant kingdom.[6][7] DMT occurs in trace amounts in mammals, where it functions as a neurotransmitter and putatively as a neuromodulator. DMT is also produced in humans; however, its production and purpose in the brain has yet to be proven or understood.[8] It is originally derived from the essential amino acid tryptophan and ultimately produced by the enzyme INMT during normal metabolism.[9] The significance of its widespread natural presence remains undetermined. DMT is structurally analogous to the neurotransmitter serotonin (5-HT) and the hormone melatonin, and furthermore functionally analogous to other psychedelic tryptamines, such as 5-MeO-DMT, bufotenin, psilocin, and psilocybin. https://youtube/watch?v=DUK2U0fqx2g
Posted on: Fri, 05 Sep 2014 04:50:36 +0000
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