#TFQOD #MBA #CAT2014 Check out our CAT Question Of the Day. Watch this space for the solution tomorrow. Answer the question based on the passage given below. Advanced age is the main risk factor for most chronic diseases and functional deficits in humans, but the fundamental mechanisms that drive ageing remain largely unknown, impeding the development of interventions that might delay or prevent age-related disorders and maximize healthy lifespan. Cellular senescence, which halts the proliferation of damaged or dysfunctional cells, is an important mechanism to constrain the malignant progression of tumor cells. Senescent cells accumulate in various tissues and organs with ageing and have been hypothesized to disrupt tissue structure and function because of the components they secrete. However, whether senescent cells are causally implicated in age-related dysfunction and whether their removal is beneficial has remained unknown. To address these fundamental questions, we made use of a biomarker for senescence, p16Ink4a, to design a novel transgene, ink-attac, for inducible elimination of p16Ink4a-positive senescent cells upon administration of a drug. Here we saw that in the BubR1 progeroid mouse background, ink-attac removes p16Ink4a-positive senescent cells upon drug treatment. In tissues—such as adipose tissue, skeletal muscle and eye—in which p16Ink4a contributes to the acquisition of age-related pathologies, life-long removal of p16Ink4a-expressing cells delayed onset of these phenotypes. Furthermore, late-life clearance attenuated progression of already established age-related disorders. These data indicate that cellular senescence is causally implicated in generating age-related phenotypes and that removal of senescent cells can prevent or delay tissue dysfunction and extend health span. This passage is most likely an extract form which of the following? OPTIONS 1) High School General Science textbook. 2) Social magazine related to Health and Fitness. 3) Newspaper Opinion Editorial. 4) Introduction of a Research Paper.
Posted on: Mon, 26 May 2014 02:30:00 +0000
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