The endocannabinoid system refers to a group of neuromodulatory lipids and their receptors that are involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory, health and it mediates the psychoactive effects of Cannabis and, broadly speaking, includes: The Cannabinoid receptors CB1 and CB2, two G protein-coupled receptors that are located in the central and peripheral nervous systems, respectively. These receptors become activated once ingested Cannabinoids bind or fit into them like keys, they the tackle the job of restoring your health. The endogenous arachidonate-based lipids, anandamide (N-arachidonoylethanolamide, AEA) and 2-arachidonoylglycerol (2-AG), these are known as Endocannabinoids and are physiological ligands for the Cannabinoid receptors. These processes or Endocannabinoids influence ALL processes in the body, enhancing them to perform better and more efficient. The enzymes that synthesize and degrade the Endocannabinoids. Unlike traditional neurotransmitters, endogenous Cannabinoids are not stored in vesicles after synthesis, but are synthesized on demand -Rodriguez de Fonseca et al., 2004). However, some evidence suggests that a pool of synthesized Endocannabinoids (namely, 2-AG) may exist without the requirement of on-demand synthesis.
Posted on: Mon, 26 Jan 2015 03:32:03 +0000
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